Lipid radicals cause light-induced retinal degeneration,Chemical Communications

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Lipid radicals cause light-induced retinal degeneration
Chemical Communications ( IF 4.9 ) Pub Date : 2017-09-12 00:00:00 , DOI: 10.1039/c7cc03387g
Masataka Enoki _{1,

2,

3,

4,

5} , Saki Shinto _{1,

2,

3,

4,

5} , Yuta Matsuoka _{1,

2,

3,

4,

5} , Ayasa Otsuka _{1,

2,

3,

4,

5} , Sachiko Kaidzu _{5,

6,

7,

8} , Masaki Tanito _{5,

6,

7,

8} , Takahiro Shibata _{5,

9,

10,

11,

12} , Koji Uchida _{13,

14,

15,

16,

17} , Akihiro Ohira _{5,

6,

7,

8} , Mayumi Yamato _{1,

2,

3,

4,

5} , Ken-ichi Yamada _{1,

2,

3,

4,

5}

Affiliation

Physical Chemistry for Life Science Laboratory
Faculty of Pharmaceutical Sciences
Kyushu University
Fukuoka
Japan
Department of Ophthalmology
Shimane University School of Medicine
Izumo
Laboratory of Food and Biodynamics
Graduate School of Bioagricultural Sciences and School of Agricultural Sciences
Nagoya University
Nagoya
Laboratory of Food Chemistry
Department of Applied Biological Chemistry
Graduate School of Agricultural and Life Sciences
The University of Tokyo
Tokyo

Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.

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