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Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multi-Site ENIGMA-PGC Study
Biological Psychiatry ( IF 10.6 ) Pub Date : 2018-02-01 , DOI: 10.1016/j.biopsych.2017.09.006
Mark W Logue 1 , Sanne J H van Rooij 2 , Emily L Dennis 3 , Sarah L Davis 4 , Jasmeet P Hayes 5 , Jennifer S Stevens 2 , Maria Densmore 6 , Courtney C Haswell 4 , Jonathan Ipser 7 , Saskia B J Koch 8 , Mayuresh Korgaonkar 9 , Lauren A M Lebois 10 , Matthew Peverill 11 , Justin T Baker 12 , Premika S W Boedhoe 13 , Jessie L Frijling 14 , Staci A Gruber 12 , Ilan Harpaz-Rotem 15 , Neda Jahanshad 3 , Sheri Koopowitz 7 , Ifat Levy 16 , Laura Nawijn 14 , Lauren O'Connor 17 , Miranda Olff 18 , David H Salat 19 , Margaret A Sheridan 20 , Jeffrey M Spielberg 21 , Mirjam van Zuiden 14 , Sherry R Winternitz 12 , Jonathan D Wolff 10 , Erika J Wolf 5 , Xin Wang 22 , Kristen Wrocklage 15 , Chadi G Abdallah 15 , Richard A Bryant 23 , Elbert Geuze 24 , Tanja Jovanovic 2 , Milissa L Kaufman 10 , Anthony P King 25 , John H Krystal 15 , Jim Lagopoulos 26 , Maxwell Bennett 26 , Ruth Lanius 27 , Israel Liberzon 25 , Regina E McGlinchey 28 , Katie A McLaughlin 11 , William P Milberg 28 , Mark W Miller 5 , Kerry J Ressler 29 , Dick J Veltman 13 , Dan J Stein 7 , Kathleen Thomaes 13 , Paul M Thompson 3 , Rajendra A Morey 30
Affiliation  

BACKGROUND Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. METHODS We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. RESULTS In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = -0.17, p = .00054), and smaller amygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p < .0063). CONCLUSIONS Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

中文翻译:

创伤后应激障碍中较小的海马体积:一项多站点 ENIGMA-PGC 研究

背景 许多研究报告说,创伤后应激障碍 (PTSD) 中的海马体和杏仁核体积较小,但研究结果并不总是一致的。在这里,我们介绍了由精神病基因组学联合会 (PGC) - 通过荟萃分析 (ENIGMA) 创伤后应激障碍工作组增强神经影像学遗传学进行的一项关于创伤后应激障碍的大规模神经影像学联合研究的结果。方法 我们分析了来自 16 个队列的 1868 名受试者(794 名 PTSD 患者)的神经影像学和临床数据,这是迄今为止最大的 PTSD 神经影像学研究。我们评估了八个皮层下结构(伏隔核、杏仁核、尾状核、海马体、苍白球、壳核、丘脑和侧脑室)的体积。我们使用了由 ENIGMA 联盟建立的标准化图像分析和质量控制流程。结果 在对所有样本进行的荟萃分析中,我们发现与暴露于创伤的对照组相比,患有当前 PTSD 的受试者的海马体明显更小 (Cohen's d = -0.17, p = .00054),杏仁核也更小 (d = -0.11, p = .025),尽管杏仁核的发现没有达到 Bonferroni 针对多个皮层下区域比较校正的显着性水平 (p < .0063)。结论 我们的研究不受已发表数据的荟萃分析的偏差影响,它代表了正在进行的合作努力的一个重要里程碑,该努力旨在检查 PTSD 的神经生物学基础和大脑对创伤的反应。025),尽管杏仁核的发现没有达到 Bonferroni 针对多个皮层下区域比较校正的显着性水平 (p < .0063)。结论 我们的研究不受已发表数据的荟萃分析的偏差影响,它代表了正在进行的合作努力的一个重要里程碑,该努力旨在检查 PTSD 的神经生物学基础和大脑对创伤的反应。025),尽管杏仁核的发现没有达到 Bonferroni 针对多个皮层下区域比较校正的显着性水平 (p < .0063)。结论 我们的研究不受已发表数据的荟萃分析的偏差影响,它代表了正在进行的合作努力的一个重要里程碑,该努力旨在检查 PTSD 的神经生物学基础和大脑对创伤的反应。
更新日期:2018-02-01
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