Wound healing on skin involves cell migration and proliferation in response to endogenous electric current. External electrical stimulation by electrical equipment is used to promote these biological processes for the treatment of chronic wounds and ulcers. Miniaturization of the electrical stimulation device for wound healing on skin will make this technology more widely available. Using flexible enzymatic electrodes and stretchable hydrogel, a stretchable bioelectric plaster is fabricated with a built‐in enzymatic biofuel cell (EBFC) that fits to skin and generates ionic current along the surface of the skin by enzymatic electrochemical reactions for more than 12 h. To investigate the efficacy of the fabricated bioelectric plaster, an artificial wound is made on the back skin of a live mouse and the wound healing is observed for 7 d in the presence and absence of the ionic current of the bioelectric plaster. The time course of the wound size as well as the hematoxylin and eosin staining of the skin section reveals that the ionic current of the plaster leads to faster and smoother wound healing. The present work demonstrates a proof of concept for the electrical manipulation of biological functions by EBFCs.

中文翻译：

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通过生物电石膏的电刺激加速皮肤上的伤口愈合

皮肤上的伤口愈合涉及响应内源电流的细胞迁移和增殖。用电气设备进行外部电刺激可促进这些生物学过程，以治疗慢性伤口和溃疡。用于皮肤伤口愈合的电刺激设备的小型化将使该技术得到更广泛的应用。使用挠性酶电极和可拉伸水凝胶，可拉伸生物电膏采用内置的酶生物燃料电池（EBFC）制成，该燃料电池适合皮肤并通过酶电化学反应在皮肤表面产生离子电流超过12小时。为了研究人造生物电石膏的功效，在活小鼠的背部皮肤上制造一个人造伤口，并在有无生物电石膏离子电流的情况下观察伤口愈合7天。伤口大小的时间进程以及皮肤切片的苏木精和曙红染色表明，膏药的离子流可导致伤口愈合更快，更顺畅。本工作证明了EBFC对生物功能进行电操纵的概念证明。