We report the identification of ω-N-methyl-4-hydroxytryptamine (norpsilocin, 1) from the carpophores of the hallucinogenic mushroom Psilocybe cubensis. The structure was elucidated by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry. Norpsilocin has not previously been reported as a natural product. It likely represents the actual psychotropic agent liberated from its 4-phosphate ester derivative, the known natural product baeocystin. We further present a simple and artifact-free extraction method that prevents dephosphorylation and therefore helps reflect the naturally occurring metabolic profile of Psilocybe mushrooms in subsequent analyses.

中文翻译：

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ω-鉴定Ñ甲基-4-羟色胺（Norpsilocin），为裸盖菇天然产物

我们报告ω-的识别Ñ甲基-4-羟色胺（norpsilocin，1从致幻蘑菇的carpophores）裸盖菇霜霉病。通过1D和2D NMR光谱以及高分辨率质谱对结构进行了阐明。以前未曾报道过Norpsilocin是天然产物。它很可能代表从其4-磷酸酯衍生物（已知的天然产物baocystin）中释放出来的实际精神药物。我们进一步提供一个简单和无伪影的提取方法，其防止去磷酸化并因此有助于反映天然存在的代谢分布裸盖菇在后续分析蘑菇。