The word chemokine is a combination of the words chemotactic and cytokine, in other words cytokines that promote chemotaxis. Hence, the term chemokine receptor refers largely to the ability to regulate chemoattraction. However, these receptors can modulate additional leukocyte functions, as exemplified by the case of CCR7 which, apart from chemotaxis, regulates survival, migratory speed, endocytosis, differentiation and cytoarchitecture. We present evidence highlighting that multifunctionality is a common feature of chemokine receptors. Based on the activities that they regulate, we suggest that chemokine receptors can be classified into inflammatory (which control both inflammatory and homeostatic functions) and homeostatic families. The information accrued also suggests that the non-chemotactic functions controlled by chemokine receptors may contribute to optimizing leukocyte functioning under normal physiological conditions and during inflammation.

中文翻译：

---

超越化学引力：白细胞中趋化因子受体的多功能性

趋化因子一词是趋化性和细胞因子的组合，换句话说，是促进趋化性的细胞因子。因此，术语趋化因子受体主要是指调节趋化性的能力。然而，这些受体可以调节额外的白细胞功能，如CCR7的例子所示，除了趋化性，CCR7还可以调节生存，迁移速度，内吞作用，分化和细胞结构。我们目前的证据强调多功能性是趋化因子受体的共同特征。根据它们调节的活性，我们建议趋化因子受体可分为炎症性（控制炎症和体内稳态功能）和稳态家族。