Psychological/physical stressors and local tissue damage increase inflammatory proteins in tissues and blood in humans and animals, in the absence of pathogenic disease. Stress-evoked cytokine/chemokine responses, or sterile inflammation, can facilitate host survival and/or negatively affect health, depending on context. Recent evidence supports the hypothesis that systemic stress-evoked sterile inflammation is initiated by the sympathetic nervous system, resulting in the elevation of exosome-associated immunostimulatory endogenous danger/damage associated molecular patterns (DAMPs) and a reduction in immunoinhibitory miRNA, which are carried in the circulation to tissues throughout the body. We propose that sterile inflammation should be considered an elemental feature of the stress response and that circulating exosomes transporting immunomodulatory signals, may play a role fundamental role in immune homeostasis.

中文翻译：

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外泌体，DAMP和miRNA：应激生理和免疫稳态的特征

在没有致病性疾病的情况下，心理/生理应激源和局部组织损伤会增加人和动物组织和血液中的炎症蛋白。根据情况，应激诱发的细胞因子/趋化因子反应或无菌炎症可促进宿主存活和/或对健康产生负面影响。最新证据支持以下假设，即系统性应激诱发的无菌炎症是由交感神经系统引发的，从而导致与外来体相关的免疫刺激性内源性危险/损伤相关分子模式（DAMPs）的升高和免疫抑制性miRNA的降低。循环到整个身体的组织。