Laminins are trimeric proteins that are major components of the basement membranes that separate endothelia and epithelia from the underlying tissue. Sixteen laminin isoforms have been described, each with distinct tissue expression patterns and functions. While laminins have a critical structural role, recent evidence also indicates that they also impact the migration and functions of immune cells. Laminins are differentially expressed upon immunity or tolerance and orientate the immune response. This review will summarize the structure of laminins, the modulation of their expression, and their interactions with the immune system. Finally, the role of the laminins in autoimmune diseases and transplantation will be discussed.

中文翻译：

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层粘连蛋白对免疫系统的调节

层粘连蛋白是三聚体蛋白，是将内皮和上皮与下层组织分开的基底膜的主要成分。已经描述了十六种层粘连蛋白同工型，每种具有不同的组织表达模式和功能。尽管层粘连蛋白具有关键的结构作用，但最近的证据也表明它们还影响免疫细胞的迁移和功能。层粘连蛋白在免疫力或耐受性上差异表达，并定向免疫反应。这篇综述将总结层粘连蛋白的结构，其表达的调节及其与免疫系统的相互作用。最后，将讨论层粘连蛋白在自身免疫性疾病和移植中的作用。