Humoral immunity is generated and maintained by antigen-specific antibodies that counter infectious pathogens. Plasma cells are the major producers of antibodies during and after infections, and each plasma cell produces some thousands of antibody molecules per second. This magnitude of secretion requires enormous quantities of amino acids and glycosylation sugars to properly build and fold antibodies, biosynthetic substrates to fuel endoplasmic reticulum (ER) biogenesis, and additional carbon sources to generate energy. Many of these processes are likely to be linked, thereby affording possibilities to improve vaccine design and to develop new therapies for autoimmunity. We review here aspects of plasma cell biology with an emphasis on recent studies and the relationships between intermediary metabolism, antibody production, and lifespan.

中文翻译：

---

浆细胞存活、分泌和压力之间的代谢联系

体液免疫是由对抗传染性病原体的抗原特异性抗体产生和维持的。浆细胞是感染期间和感染后抗体的主要生产者，每个浆细胞每秒产生数千个抗体分子。这种分泌量需要大量的氨基酸和糖基化糖来正确构建和折叠抗体，需要生物合成底物来促进内质网 (ER) 生物发生，以及额外的碳源来产生能量。许多这些过程可能相互关联，从而为改进疫苗设计和开发新的自身免疫疗法提供了可能性。我们在这里回顾了浆细胞生物学的各个方面，重点是最近的研究以及中间代谢、抗体产生和寿命之间的关系。