cGMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) sensing has emerged as a key regulator of innate immune responses to both exogenous and endogenous DNA. Recent studies reveal critical roles for this pathway in natural antitumor immunity across cancer types as well as in immune checkpoint blockade therapy. However, it is also clear that some tumors evade cGAS–STING-mediated immune responses, and immunomodulatory therapeutics are currently being explored to target this pathway. Finally, we also discuss recent observations that cGAS–STING-mediated inflammation may promote tumor initiation, growth, and metastasis in certain malignancies and how this may complicate the utility of this pathway in therapeutic development.

中文翻译：

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cGAS-STING和癌症：在肿瘤免疫和发育中的二分作用

cGMP-AMP合酶（cGAS）-干扰素基因刺激（STING）已成为对外源和内源DNA固有免疫反应的关键调节剂。最近的研究揭示了该途径在跨癌症类型的天然抗肿瘤免疫以及免疫检查点封锁疗法中的关键作用。但是，也很明显，一些肿瘤逃避了cGAS–STING介导的免疫反应，目前正在研究针对这种途径的免疫调节疗法。最后，我们还讨论了最近的观察结果，即cGAS–STING介导的炎症可能会促进某些恶性肿瘤的肿瘤发生，生长和转移，以及这如何使该途径在治疗开发中的作用复杂化。