Mechanisms of tolerance initiated in the thymus are indispensable for establishing immune homeostasis, but they may not be sufficient to prevent tissue-specific autoimmune diseases. In the periphery, dendritic cells (DCs) play a crucial tolerogenic role, extending the maintenance of immune homeostasis and blocking autoimmune responses. We review here these essential roles of DCs in orchestrating mechanisms of peripheral T cell tolerance as determined by targeted delivery of defined antigens to DCsin vivoin combination with various genetic modifications of DCs. Further, we discuss how DC functions empowered by specific delivery of T cell antigens could be harnessed for tolerance induction in clinical settings.

中文翻译：

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树突状细胞作为外周耐受的诱导物

胸腺中起始的耐受机制对于建立免疫稳态是必不可少的，但它们可能不足以预防组织特异性自身免疫性疾病。在外围，树突状细胞（DC）发挥着至关重要的致癌作用，扩展了免疫稳态的维持并阻断了自身免疫反应。我们在这里回顾了DC在外周T细胞耐受的协调机制中的这些基本作用，这是通过将定义的抗原靶向递送至DCsin vivoin与DC的各种遗传修饰相结合来确定的。此外，我们讨论了如何利用T细胞抗原特异性递送所赋予的DC功能，以在临床环境中诱导耐受性。