γδ T cells play a role in immune surveillance because they recognize stress-induced surface molecules and metabolic intermediates that are frequently dysregulated in transformed cells. Hence, γδ T cells have attracted much interest as effector cells in cell-based immunotherapy. Recently, however, it has been realized that γδ T cells can also promote tumorigenesis through various mechanisms including regulatory activity and IL-17 production. In this review we outline both the pathways involved in cancer cell recognition and killing by γδ T cells as well as current evidence for their protumorigenic activity in various models. Finally, we discuss strategies to improve the tumor reactivity of γδ T cells and to counteract their protumorigenic activities, which should open improved perspectives for their clinical application.

中文翻译：

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γδT淋巴细胞在抗肿瘤免疫中的模糊作用

γδT细胞在免疫监视中起着重要作用，因为它们可以识别压力诱导的表面分子和通常在转化细胞中失调的代谢中间产物。因此，在基于细胞的免疫疗法中，γδT细胞作为效应细胞引起了人们的极大兴趣。然而，最近，已经认识到γδT细胞还可以通过多种机制促进肿瘤发生，所述机制包括调节活性和IL-17产生。在这篇综述中，我们概述了参与癌细胞识别和γδT细胞杀伤的途径，以及它们在各种模型中的致瘤活性的当前证据。最后，我们讨论了改善γδT细胞的肿瘤反应性并抵消其促癌作用的策略，这将为他们的临床应用打开更广阔的前景。