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In Vivo Magnetic Recording of Neuronal Activity
Neuron ( IF 16.2 ) Pub Date : 2017-08-24 00:00:00 , DOI: 10.1016/j.neuron.2017.08.012
Laure Caruso , Thomas Wunderle , Christopher Murphy Lewis , Joao Valadeiro , Vincent Trauchessec , Josué Trejo Rosillo , José Pedro Amaral , Jianguang Ni , Patrick Jendritza , Claude Fermon , Susana Cardoso , Paulo Peixeiro Freitas , Pascal Fries , Myriam Pannetier-Lecoeur

Neuronal activity generates ionic flows and thereby both magnetic fields and electric potential differences, i.e., voltages. Voltage measurements are widely used but suffer from isolating and smearing properties of tissue between source and sensor, are blind to ionic flow direction, and reflect the difference between two electrodes, complicating interpretation. Magnetic field measurements could overcome these limitations but have been essentially limited to magnetoencephalography (MEG), using centimeter-sized, helium-cooled extracranial sensors. Here, we report onin vivomagnetic recordings of neuronal activity from visual cortex of cats withmagnetrodes, specially developed needle-shaped probes carrying micron-sized, non-cooled magnetic sensors based on spin electronics. Event-related magnetic fields inside the neuropil were on the order of several nanoteslas, informing MEG source models and efforts for magnetic field measurements through MRI. Though the signal-to-noise ratio is still inferior to electrophysiology, this proof of concept demonstrates the potential to exploit the fundamental advantages of magnetophysiology.

中文翻译:

体内神经元活动磁记录

神经元活动产生离子流,从而产生磁场和电势差,即电压。电压测量已被广泛使用,但是具有源和传感器之间组织的隔离和拖尾特性,对离子流方向无知,并且会反映两个电极之间的差异,使解释变得复杂。磁场测量可以克服这些局限性,但是使用厘米大小的氦冷却颅外传感器,磁场测量基本上仅限于脑磁图(MEG)。在这里,我们报道了具有磁棒的猫的视觉皮层上神经元活动的体内磁记录,磁针是专门开发的针形探针,带有基于自旋电子学的微米级非冷却磁传感器。Neuropil内部与事件相关的磁场大约为数个纳米特斯拉,从而为MEG源模型和通过MRI进行磁场测量提供了信息。尽管信噪比仍不如电生理学,但这一概念证明证明了利用磁生理学基本优点的潜力。
更新日期:2017-09-20
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