Abstract Alginate nanofibers were prepared in the presence of poly(ethylene oxide) (PEO), a surfactant Pluronic F-127, and a model drug (ciprofloxacin hydrochloride, CpHCl), all mixed prior to electrospinning. It was demonstrated that addition of a carrier polymer (PEO) and a small amount of surfactant are necessary to obtain uniform alginate fibers with cylindrical shape and regular morphology. Importantly, PEO was completely removed from the resulting nanofibers during cross-linking and stabilization post-treatment. The stable alginate fibers loaded with CpHCl were examined by scanning electron microscopy and the average diameter of the fibers ranged from 109 nm (unloaded fibers) to 161 nm (loaded fibers). The release of a studied antibiotic from the nanofibers, characterized by a final loading efficiency of 51%, was tested in physiological conditions. It was revealed that ca. 24% of CpHCl is released during first 20 h with combined transport mechanism, however with the predominant contribution of Fickian diffusion.

中文翻译：

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负载盐酸环丙沙​​星的电纺海藻酸盐纳米纤维的制备与表征

摘要 在聚（环氧乙烷）（PEO）、表面活性剂 Pluronic F-127 和模型药物（盐酸环丙沙​​星，CpHCl）存在下制备海藻酸盐纳米纤维，在静电纺丝之前将所有材料混合。结果表明，需要添加载体聚合物 (PEO) 和少量表面活性剂才能获得具有圆柱形状和规则形态的均匀海藻酸盐纤维。重要的是，在交联和稳定后处理过程中，PEO 从所得纳米纤维中完全去除。通过扫描电子显微镜检查负载有 CpHCl 的稳定藻酸盐纤维，纤维的平均直径范围为 109 nm（未负载纤维）至 161 nm（负载纤维）。从纳米纤维中释放所研究的抗生素，其最终负载效率为 51%，在生理条件下进行了测试。据透露，大约。24% 的 CpHCl 在前 20 小时内通过联合运输机制释放，但主要贡献是 Fickian 扩散。