Mg-substituted hydroxyapatite (HAp) bioceramic microspheres were prepared by spray drying and subsequent processing at 1173, 1273 and 1373 K. Influence of various Mg substitution levels (up to 0.84 ± 0.10 wt%) on physicochemical properties of the HAp bioceramic microspheres was evaluated. Obtained results were used for the elucidation of the compositional and structural characteristics of the microspheres in conjunction with adsorption of protein, namely, bovine serum albumin (BSA). The primary difference among the microspheres processed at various temperature was the presence or absence of the micropores (<2 nm in diameter) and mesopores (between 2 and 50 nm). Presence of the micro- and mesopores resulted in higher specific surface area (SSA), enhanced solubility, i.e., ion release, and, accordingly, increase in the amount of BSA adsorbed on the microspheres. Furthermore, the BSA adsorption capacity of the microspheres decreased with increasing Mg content despite of higher SSA.

通过喷雾干燥并随后在1173、1273和1373 K下加工制备Mg取代的羟基磷灰石（HAp）生物陶瓷微球。评估了各种Mg取代水平（最高0.84±0.10 wt％）对HAp生物陶瓷微球的理化性质的影响。将获得的结果用于阐明微球的组成和结构特征，并结合蛋白质即牛血清白蛋白（BSA）的吸附。在不同温度下加工的微球之间的主要区别是存在或不存在微孔（直径<2 nm）和中孔（2至50 nm）。微孔和中孔的存在导致更高的比表面积（SSA），增强的溶解度，即离子释放，并因此增加了微球上吸附的BSA的数量。此外，尽管SSA较高，但随着Mg含量的增加，微球对BSA的吸附能力下降。