We took advantage of gasotransmitter H₂S as a chemical reaction-based trigger for controlled release of doxorubicin which is precoordinated by copper ions and enclosed in horse spleen apoferritin. The nanocomposite is stable at physiological pH and temperature before H₂S activation. The drug release process avoids disassembly of protein shells and is controllable by the strong affinity of sulfide with copper ions. The in vitro cytotoxicity assay indicates the antitumor effect of doxorubicin toward tumor cells could be achievable by H₂S activation.

中文翻译：

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H ₂ S活化的药物从蛋白笼中释放

我们利用气体递质H ₂ S作为基于化学反应的触发器来控制阿霉素的释放，该阿霉素由铜离子预先配位并封闭在马脾脱铁蛋白中。在H ₂ S活化之前，该纳米复合材料在生理pH和温度下是稳定的。药物释放过程避免了蛋白质壳的分解，并且可以通过硫化物与铜离子的强亲和力来控制。体外细胞毒性试验表明，通过H ₂ S激活可以达到阿霉素对肿瘤细胞的抗肿瘤作用。