A two-amino-acid substitution in the transcription factor RORγt disrupts its effect in establishing the transcriptional program of TH17 cells while leaving its function in the development of thymocytes and lymphoid-tissue–inducer cells largely intact.

中文翻译：

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解开RORγt的流形函数

转录因子RORγt中的两个氨基酸取代破坏了它在建立TH17细胞转录程序中的作用，而在胸腺细胞和淋巴组织诱导细胞的发育中却保持了完整的功能。