Langerhans cells (LCs) are epidermis-resident antigen-presenting cells that share a common ontogeny with macrophages but function as dendritic cells (DCs). Their development, recruitment and retention in the epidermis is orchestrated by interactions with keratinocytes through multiple mechanisms. LC and dermal DC subsets often show functional redundancy, but LCs are required for specific types of adaptive immune responses when antigen is concentrated in the epidermis. This Review will focus on those developmental and functional properties that are unique to LCs.

中文翻译：

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鼠表皮朗格汉斯细胞的个体发育和功能。

朗格汉斯细胞（LC）是表皮驻留的抗原呈递细胞，与巨噬细胞共享共同的个体发育，但起着树突状细胞（DC）的作用。它们的发育，募集和在表皮中的滞留是通过多​​种机制与角质形成细胞相互作用而精心安排的。LC和真皮DC子集通常显示功能冗余，但是当抗原集中在表皮中时，特定类型的适应性免疫反应需要LC。本评论将重点关注LC独有的那些开发和功能特性。