Small drug molecules are widely developed and used in the pharmaceutical industry. In the past few years, loading and delivering such molecules using polymer-shell colloidosomes has attracted interest. Traditional polymer capsules fail to encapsulate low-molecular-weight materials for long times, since they are inherently porous and permeable for small molecules. In this paper, we report a method for encapsulating an anticancer drug with small molecule weight, for cell viability tests. The silver-coated colloidosomes are prepared by making an aqueous core capsule with a polymer shell and then adding AgNO₃, surfactant, and l-ascorbic acid to form a second shell. The capsules are impermeable and can be triggered using ultrasound. We propose to use the capsules as drug carriers. The silver demonstrates a low cytotoxicity for up to 10 capsules per cell. After the silver shells are triggered by ultrasound, the released doxorubicin, the broken silver fragments, and the doxorubicin loading on the capsule surface all kill cells. The results demonstrate a nonpermeable silver-shell microcapsule with ultrasound sensitivity for potential medical applications.

中文翻译：

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银包胶体作为抗癌药物的载体

小药物分子被广泛开发并用于制药工业。在过去的几年中，使用聚合物-壳胶体装载和递送此类分子引起了人们的兴趣。传统的聚合物胶囊无法长时间封装低分子量材料，因为它们固有地对小分子具有多孔性和渗透性。在本文中，我们报告了一种封装小分子量抗癌药物的方法，用于细胞活力测试。制备银包衣的胶体的方法是，先制成带有聚合物壳的水性核胶囊，然后加入AgNO ₃，表面活性剂和L-抗坏血酸形成第二个壳。胶囊是不可渗透的，可以使用超声波触发。我们建议将胶囊用作药物载体。银显示出低的细胞毒性，每个细胞最多10个胶囊。超声波触发银壳后，释放的阿霉素，破碎的银碎片以及装载在胶囊表面的阿霉素均会杀死细胞。结果证明了具有超声敏感性的不可渗透的银壳微胶囊用于潜在的医学应用。