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Copper-Catalyzed Borylacylation of Activated Alkenes with Acid Chlorides
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2017-09-18 11:32:26 , DOI: 10.1002/anie.201707323
Yuan Huang 1 , Kevin B. Smith 1 , M. Kevin Brown 1
Affiliation  

Give 'em the new one, two: A range of activated alkenes underwent rapid copper-catalyzed borylacylation at room temperature at low catalyst loadings (see scheme). The reaction involves borylcupration of the alkene and capture of the resulting alkyl–copper intermediate with an acid chloride. In the case of vinyl arenes, the transformation could be carried out in an enantioselective manner.

中文翻译:

铜与酰基氯催化活化烯烃的硼烷基化

给他们一个新的,两个:在室温下,在低催化剂负载下,一系列活化烯烃迅速进行了铜催化的硼烷基化反应(参见方案)。该反应包括烯丙基硼化,并用酰氯捕获生成的烷基铜中间体。在乙烯基芳烃的情况下,可以以对映选择性的方式进行转化。
更新日期:2017-09-19
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