Lassa fever afflicts tens of thousands of people in West Africa annually. The rapid progression of patients from febrile illness to fulminant syndrome and death provides incentive for development of clinical prognostic markers that can guide case management. The small molecule profile of serum from febrile patients triaged to the Viral Hemorrhagic Fever Ward at Kenema Government Hospital in Sierra Leone was assessed using untargeted Ultra High Performance Liquid Chromatography Mass Spectrometry. Physiological dysregulation resulting from Lassa virus (LASV) infection occurs at the small molecule level. Effects of LASV infection on pathways mediating blood coagulation, and lipid, amino acid, nucleic acid metabolism are manifest in changes in the levels of numerous metabolites in the circulation. Several compounds, including platelet activating factor (PAF), PAF-like molecules and products of heme breakdown emerged as candidates that may prove useful in diagnostic assays to inform better care of Lassa fever patients.

拉萨热每年折磨西非成千上万人。患者从高热疾病发展到暴发性综合征和死亡的迅速发展为发展可指导病例管理的临床预后指标提供了动力。使用非靶向超高效液相色谱质谱仪评估了在塞拉利昂凯内玛政府医院分流到病毒性出血热病房的高热患者血清的小分子分布。由拉萨病毒（LASV）感染引起的生理失调发生在小分子水平。LASV感染对介导凝血的途径的影响，脂质，氨基酸，核酸代谢表现为循环中许多代谢物水平的变化。几种化合物