Epoxyquinone natural products continue to attract the attention of organic synthesis community worldwide, owing to their increasingly diverse and complex molecular architectures and broad spectrum biological activities associated with them. The last decade, in particular, has witnessed considerable activity and advances towards the total synthesis of this family of natural products with some notable successes. These efforts, deploying appropriate, contextual and emergent synthetic methodologies have led to the total synthesis of numerous epoxyquinone natural products spread over the entire structural landscape, with the added value of generating new chemical diversity space around their scaffold. This flurry of activity since 2005 lends some urgency to provide an update that documents and highlights the achievements in the intervening years and reflects on the new opportunities and challenges that lie ahead.

环氧醌天然产物由于其日益多样化和复杂的分子结构以及与之相关的广谱生物活性而继续吸引着全世界有机合成界的关注。特别是在过去的十年中，目睹了相当多的活动，并朝着完全合成这一天然产品系列迈进了一步，并取得了一些显著成就。这些努力，采用适当的，因地制宜的和新出现的合成方法，已导致对整个结构景观中分布的许多环氧醌天然产物进行全合成，并具有在其支架周围产生新的化学多样性空间的附加价值。