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Designing cooperatively folded abiotic uni- and multimolecular helix bundles
Nature Chemistry ( IF 21.8 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1038/nchem.2854
Soumen De , Bo Chi , Thierry Granier , Ting Qi , Victor Maurizot , Ivan Huc

Designing cooperatively folded abiotic uni- and multimolecular helix bundles

Nature Chemistry, Published online: 18 September 2017; doi:10.1038/nchem.2854

Rationally designed arrays of hydrogen bonds between aromatic oligoamide segments have now been shown to generate abiotic helix-turn-helix and unexpected dimeric and trimeric helix bundle motifs. These structures show kinetic and thermodynamic stability, and cooperative folding in nonpolar solvents.



中文翻译:

设计合作折叠的非生物单分子和多分子螺旋束

设计合作折叠的非生物单分子和多分子螺旋束

《自然化学》,在线发布:2017年9月18日; doi:10.1038 / nchem.2854

现已证明,合理设计的芳香族低酰胺片段之间的氢键阵列可产生非生物螺旋-转-螺旋以及意外的二聚体和三聚体螺旋束基序。这些结构显示出动力学和热力学稳定性,以及在非极性溶剂中的协同折叠。

更新日期:2017-09-18
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