Deuterium incorporations from [²H₁]-(1R,2R) and [²H₁]-(1S,2R) glycerols into the fluorine containing antibiotic nucleocidin, in Streptomyces calvus indicate that one deuterium atom is incorporated at the C-5′ site of nucleocidin from each of these isotopomers of glycerol. Two deuteriums become incorporated at C-5′ of nucleocidin after a feeding experiment with [²H₅]-glycerol. These observations indicate that there is no obligate oxidation of the pro-R hydroxymethyl group of glycerol as it progresses through the pentose phosphate pathway and becomes incorporated into the fluorinated antibiotic.

中文翻译：

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将[ ² H ₁ ]-（1 R，2 R）-和[ ² H ₁ ]-（1 S，2 R）-甘油掺入产犊链霉菌中的抗生素核苷

从[ ² H ₁ ]-（1 R，2 R）和[ ² H ₁ ]-（1 S，2 R）甘油向氟链霉菌亲核素中掺入氘表明，氘原子掺入了一个氘原子。来自甘油的每个这些同位素异构体的核苷亲和素的C-5'位点。在用[ ² H ₅ ]-甘油进行补料实验后，两个氘在核仁亲和素的C-5'处结合。这些观察结果表明pro-R没有专一氧化 甘油的羟甲基通过戊糖磷酸途径发展并掺入氟化抗生素中。