Two for the price of one: GfsF is a multifunctional P450 monooxygenase that catalyzes epoxidation and subsequent hydroxylation in the biosynthesis of FD-891. X-ray structural and biochemical analyses of GfsF revealed two distinct substrate binding modes for the epoxidation and hydroxylation reactions, which explained how GfsF regulates the order of two oxidative reactions.

中文翻译：

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参与FD-891生物合成的双功能P450单加氧酶GfsF对底物的识别

两种价格一价：GfsF是多功能P450单加氧酶，可催化FD-891生物合成中的环氧化和随后的羟基化。X射线对GfsF的结构和生化分析揭示了环氧化和羟基化反应的两种不同的底物结合模式，这解释了GfsF如何调节两个氧化反应的顺序。