当前位置: X-MOL 学术Ann. Oncol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis
Annals of Oncology ( IF 50.5 ) Pub Date : 2017-07-19 , DOI: 10.1093/annonc/mdx278
Q. Wei , Z. Ye , X. Zhong , L. Li , C. Wang , R.E. Myers , J.P. Palazzo , D. Fortuna , A. Yan , S.A. Waldman , X. Chen , J.A. Posey , A. Basu-Mallick , B.H. Jiang , L. Hou , J. Shu , Y. Sun , J. Xing , B. Li , H. Yang

Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC). Genomic heterogeneity has been reported in various solid malignancies, but remains largely under-explored in metastatic CRC tumors, especially in primary to metastatic tumor evolution.

中文翻译:

匹配的原发性和转移性肿瘤的多区域全基因组测序揭示了基因组异质性,并建议在结肠直肠癌转移中进行多克隆接种

远处转移占大肠癌(CRC)死亡的90%。在各种实体恶性肿瘤中均已报道了基因组异质性,但在转移性CRC肿瘤中,尤其是在原发性至转移性肿瘤的进化中,仍存在很大的探索不足。
更新日期:2017-09-18
down
wechat
bug