The role of tumor-infiltrating lymphocytes (TILs) in breast cancer has been extensively studied over the last decade. High TILs levels have been associated with pathological response rate in the neoadjuvant setting and with better outcomes in the adjuvant setting. However, little attention has been paid to changes in TILs and residual TIL levels after neoadjuvant chemotherapy (NAC). We investigated TIL levels before, after chemotherapy, and their dynamics during treatment; and we assessed the correlation of these levels with response to NAC and prognosis.

中文翻译：

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新辅助化疗后基质细胞浸润与侵袭性残留疾病和HER2阳性乳腺癌的无病生存期降低相关

在过去的十年中，已经广泛研究了肿瘤浸润淋巴细胞（TILs）在乳腺癌中的作用。在新辅助治疗中，高TILs水平与病理反应率相关，在辅助治疗中与更好的预后相关。但是，新辅助化疗（NAC）后TIL和残留TIL水平的变化很少引起关注。我们调查了化疗前后的TIL水平及其在治疗过程中的动态。我们评估了这些水平与对NAC的反应和预后的相关性。