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Stromal inflammation, necrosis and HER2 overexpression in ductal carcinoma in situ of the breast: another causality dilemma?
Annals of Oncology ( IF 50.5 ) Pub Date : 2017-07-11 , DOI: 10.1093/annonc/mdx253 M. Van Bockstal , L. Libbrecht , G. Floris , K. Lambein , S. Pinder
Annals of Oncology ( IF 50.5 ) Pub Date : 2017-07-11 , DOI: 10.1093/annonc/mdx253 M. Van Bockstal , L. Libbrecht , G. Floris , K. Lambein , S. Pinder
We read with interest the manuscript of Pruneri et al. [1] concerning tumor-infiltrating lymphocytes (TILs) in ductal carcinoma in situ (DCIS). TILs were retrospectively studied in an extensive cohort of 1488 patients. DCIS studies are often underpowered due to limited patient numbers, and robust statistical analysis is frequently hampered by low recurrence rates. Therefore, Pruneri et al. [1] provide truly valuable information for the scientific and oncologic community. However, we do have some remarks regarding the conclusions of this study.
中文翻译:
乳腺导管癌中的间质性炎症,坏死和HER2过表达:另一个因果关系困境?
我们感兴趣地阅读了Pruneri等人的手稿。[1]关于导管原位癌(DCIS)中的肿瘤浸润淋巴细胞(TILs )。回顾性研究了1488名患者的TIL。由于患者人数有限,DCIS研究通常动力不足,而低复发率常常妨碍可靠的统计分析。因此,Pruneri等。[1]为科学和肿瘤学界提供真正有价值的信息。但是,对于本研究的结论,我们确实有一些评论。
更新日期:2017-09-18
中文翻译:
乳腺导管癌中的间质性炎症,坏死和HER2过表达:另一个因果关系困境?
我们感兴趣地阅读了Pruneri等人的手稿。[1]关于导管原位癌(DCIS)中的肿瘤浸润淋巴细胞(TILs )。回顾性研究了1488名患者的TIL。由于患者人数有限,DCIS研究通常动力不足,而低复发率常常妨碍可靠的统计分析。因此,Pruneri等。[1]为科学和肿瘤学界提供真正有价值的信息。但是,对于本研究的结论,我们确实有一些评论。