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Editorial: Mendelian Randomization Analysis Identifies Body Mass Index and Fasting Insulin as Potential Causal Risk Factors for Pancreatic Cancer Risk
Journal of the National Cancer Institute ( IF 10.3 ) Pub Date : 2017-04-28 , DOI: 10.1093/jnci/djx043
Konstantinos K Tsilidis 1, 2 , James Y Dai 3 , Ulrike Peters 3, 4
Affiliation  

In this issue of the Journal, Carreras-Torres and colleagues present evidence for a potential causal role of body mass index (BMI) and fasting insulin with risk of pancreatic cancer in 7110 cases and 7264 controls (1). Specifically, genetically increased levels of BMI and fasting insulin were associated with an increased risk of pancreatic cancer; the association with fasting insulin was limited to men. No evidence of a causal association was observed for type II diabetes, fasting glucose, glucose at two hours postchallenge, height, waist-to-hip circumference ratio, and four lipids (eg, total cholesterol, high- and low-density lipoprotein cholesterol, and triglycerides).

中文翻译:

社论:孟德尔随机分析确定体重指数和空腹胰岛素为胰腺癌风险的潜在因果因素

在本期《华尔街日报》上,Carreras-Torres及其同事提供了证据,这些证据表明体重指数(BMI)和空腹胰岛素有胰腺癌风险的潜在因果作用(7110例和7264例对照)(1)。具体而言,基因增加的BMI和空腹胰岛素水平与胰腺癌的风险增加有关。与空腹胰岛素的关联仅限于男性。没有观察到II型糖尿病,空腹血糖,攻击后两小时血糖,身高,腰围与臀围比以及四种脂质(例如总胆固醇,高密度和低密度脂蛋白胆固醇,和甘油三酸酯)。
更新日期:2017-04-28
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