Systemic immune-mediated diseases (SIDs) include autoimmune and autoinflammatory diseases (AD) affecting at least two-organ systems.¹ Autoinflammatory diseases refer to a growing family of conditions characterised by episodes of unprovoked inflammation in the absence of high autoantibody titres or auto reactive T lymphocytes, reflecting a primary innate immune system dysfunction.¹ Conversely, autoimmune diseases are characterised by aberrant B, T and dendritic cell responses, leading to a break in tolerance against self-antigens, with predominantly cell-mediated or autoantibody-mediated responses in genetically susceptible individuals.^2–11 Autoantibodies (AAbs), when detectable, can promote inflammatory responses via immune complex formation and may directly affect target organ function,¹⁰ e.g. resulting, in cardiac autoimmunity, in electrical disturbance, cardiomyocyte dysfunction or loss and heart failure.^12–15 However, a dichotomous classification does not reflect clinical evidence and...

中文翻译：

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诊断和处理系统性免疫介导的疾病中的心肌受累：欧洲心脏病学会心肌和心包疾病工作组的立场声明

全身性免疫介导的疾病（SID）包括影响至少两个器官系统的自身免疫性疾病和自身炎症性疾病（AD）。¹自身炎症性疾病是指以自身抗体滴度高或自身反应性T淋巴细胞缺乏为特征，无反应性炎症发作为特征的生长中的疾病家族，反映出原发性先天免疫系统功能异常。¹相反，自身免疫性疾病的特征是B，T和树突状细胞反应异常，导致对自身抗原的耐受性下降，在遗传易感人群中主要是细胞介导的或自身抗体介导的反应。^2-11自身抗体（AAbs）可检测时，可通过免疫复合物的形成促进炎症反应，并可能直接影响靶器官功能^10，例如，导致心脏自身免疫，电障碍，心肌细胞功能障碍或丧失和心力​​衰竭。^12-15但是，二分分类不能反映临床证据，并且...