Eosinophils are a prominent cell type in particular host responses such as the response to helminth infection and allergic disease. Their effector functions have been attributed to their capacity to release cationic proteins stored in cytoplasmic granules by degranulation. However, eosinophils are now being recognized for more varied functions in previously underappreciated diverse tissue sites, based on the ability of eosinophils to release cytokines (often preformed) that mediate a broad range of activities into the local environment. In this Review, we consider evolving insights into the tissue distribution of eosinophils and their functional immunobiology, which enable eosinophils to secrete in a selective manner cytokines and other mediators that have diverse, 'non-effector' functions in health and disease.

中文翻译：

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组织驻留性嗜酸性粒细胞的功能

嗜酸性粒细胞是特别是宿主反应（例如对蠕虫感染和过敏性疾病的反应）的主要细胞类型。它们的效应子功能归因于它们通过脱粒释放储存在细胞质颗粒中的阳离子蛋白的能力。然而，基于嗜酸性粒细胞释放介导广泛范围的活动进入局部环境的细胞因子（通常是预先形成的）的能力，现已认识到嗜酸性粒细胞在先前未被充分认识的不同组织部位具有更多样化的功能。在这篇综述中，我们考虑了对嗜酸性粒细胞的组织分布及其功能免疫生物学的不断发展的见解，使嗜酸性粒细胞能够选择性地分泌在健康和疾病中具有多种“非效应”功能的细胞因子和其他介体。