Various sulfenylated heteroarenes were synthesized by a copper‐mediated C−H thiolation, which was assisted by a 2‐(pyridin‐2‐yl)isopropylamine (PIP‐amine) directing group. The reaction features a broad substrate scope, good functional group tolerance, ligand‐ and metal‐oxidant‐free conditions, exceptional compatibility with aliphatic disulfides, and excellent yields, providing a highly efficient approach to the biologically important sulfenylated heteroarenes.

中文翻译：

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在无配体和无金属氧化剂的条件下，铜介导的未活化杂芳基CH键与二硫键的硫杂化

通过铜介导的CH巯基化反应合成了各种亚磺化杂芳基，并辅以2-（吡啶-2-基）异丙胺（PIP-胺）导向基团。该反应具有广泛的底物范围，良好的官能团耐受性，无配体和金属氧化剂的条件，与脂肪族二硫化物的优异相容性以及优异的收率，为生物学上重要的亚磺化杂芳烃提供了一种高效方法。