It is significantly important to design enzyme-free electrocatalyst for sensitive and selective detection of glucose (Glu). In this paper, we report that metallic nickel nitride nanosheet on Ti mesh (Ni₃N NS/Ti) behaves as an efficient three-dimensional catalyst electrode for Glu electro-oxidation under alkaline conditions. We further demonstrate the use of such Ni₃N NS/Ti as a non-enzymatic electrochemical Glu sensor superior in analytical performances. The introduction of the Ni₃N NS/Ti can provide a high surface area and lead to high sensitivity to Glu. This sensor shows a fast amperometric response toward Glu and can achieve steady state current density within 5 s, a detection range of 0.2 μM–1.5 mM, a detection limit of 0.06 μM (S/N = 3), a response sensitivity of 7688 μA mM⁻¹ cm⁻², and satisfactory selectivity and reproducibility. In addition, it also works effectively for Glu detection in human blood serum, promising its application toward determination of Glu in real samples.

设计无酶的电催化剂对葡萄糖（Glu）的灵敏和选择性检测非常重要。在本文中，我们报道了Ti网格（Ni ₃ N NS / Ti）上的金属氮化镍纳米片可作为碱性条件下Glu电氧化的高效三维催化剂电极。我们进一步证明了这种Ni ₃ N NS / Ti作为分析性能优异的非酶电化学Glu传感器的使用。Ni ₃的介绍N NS / Ti可以提供较大的表面积并导致对Glu的高灵敏度。该传感器显示出对Glu的快速安培响应，可以在5 s内达到稳态电流密度，检测范围为0.2 μM–1.5 mM，检测极限为0.06μM（S / N = 3），响应灵敏度为7688μA mM ^-1  cm ^-2，并且具有令人满意的选择性和重现性。此外，它还可以有效检测人血清中的Glu，有望将其用于测定实际样品中的Glu。