A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of α-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T-cell epitope PADRE, and the model CD8+ T-cell epitope SIINFEKL, each of which could be incorporated into supramolecular multiepitope nanofibers in a modular fashion.

中文翻译：

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基于α-螺旋肽纳米纤维的超分子疫苗平台

设计了一种超分子肽疫苗系统，其中带有抗原决定基的肽自组装成几乎完全由α-螺旋结构组成的细长纳米纤维。纳米纤维易于被抗原呈递细胞内化，并在小鼠中产生强大的抗体，CD4 + T细胞和CD8 + T细胞反应，而无需补充佐剂。研究的抗原决定簇包括来自表皮生长因子受体III类变体（EGFRvIII）的癌症B细胞抗原决定簇，通用CD4 + T细胞抗原决定簇PADRE和模型CD8 + T细胞抗原决定簇SIINFEKL，每种都可以整合到超分子多表位中纳米纤维以模块化的方式。