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Recent advances in AC electrokinetic sample enrichment techniques for biosensor development
Sensors and Actuators B: Chemical ( IF 8.4 ) Pub Date : 2017-09-15 , DOI: 10.1016/j.snb.2017.09.069
Alinaghi Salari , Michael Thompson

Integration of biosensing techniques with microfluidics has enabled less sample consumption and increased sensitivity. In addition, it offers a potential improvement with respect to slow diffusion-limited sensing, as well as the incorporation of several sample handling parts into a single lab-on-a-chip device. One highly efficient technique in microfluidics that can be utilized in pre-sensing sample preparation steps such as sorting, separation, trapping, enrichment, and labelling is electrokinetics. AC electroosmosis, AC electrothermal, and dielectrophoresis are among the highly applicable electrokinetic methods used for pre-sensing sample preparation for enhancing sensitivity, limit-of-detection, and selectivity of biosensing devices. In this review article, we focus on these three electrokinetic techniques used for sample enrichment in the field of biosensing technology. First, the working principals of electrothermal, electroosmosis, and dielectrophoresis are characterized, and then their recent advances and major achievements in sample enrichment for biosensors are discussed



中文翻译:

用于生物传感器开发的交流电动样品富集技术的最新进展

将生物传感技术与微流控技术相集成,可以减少样品消耗并提高灵敏度。此外,相对于缓慢的扩散受限感测以及将多个样品处理部件合并到单个芯片实验室设备中,它还提供了潜在的改进。电动势是一种可用于预感测样品制备步骤(例如分选,分离,捕获,富集和标记)的微流控技术,是一种高效的技术。交流电渗,交流电热和介电电泳是用于预感样品制备的高度适用的电动方法,可用于增强灵敏度,检测限和生物传感设备的选择性。在这篇评论文章中,我们专注于在生物传感技术领域中用于样品富集的这三种电动技术。首先,对电热,电渗和介电电泳的工作原理进行了表征,然后讨论了它们的最新进展以及在生物传感器样品富集方面的主要成就。

更新日期:2017-09-15
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