Drug Discovery Today ( IF 7.4 ) Pub Date : 2017-09-15 , DOI: 10.1016/j.drudis.2017.08.011 Cláudia Azevedo , Maria Helena Macedo , Bruno Sarmento
The intracellular delivery of nanomaterials and drugs has been attracting increasing research interest, mainly because of their important effects and functions in several organelles. Targeting specific organelles can help treat or decrease the symptoms of diabetes, cancer, infectious, and autoimmune diseases. Tuning biological and chemical properties enables the creation of functionalized nanomaterials with enhanced intracellular uptake, ability to escape premature lysosome degradation, and to reach a specific target. Here, we provide an update of recent advances in the intracellular delivery mechanisms that could help drugs reach their target more efficiently.
中文翻译:
增强纳米材料细胞内递送的策略
纳米材料和药物的细胞内递送已引起越来越多的研究兴趣,这主要是由于它们在几个细胞器中的重要作用和功能。靶向特定细胞器可以帮助治疗或减轻糖尿病,癌症,传染性和自身免疫性疾病的症状。调节生物学和化学性质使得能够创建功能化的纳米材料,其具有增强的细胞内摄取,逃避过早的溶酶体降解和达到特定目标的能力。在这里,我们提供了细胞内递送机制的最新进展的最新信息,可以帮助药物更有效地达到其靶标。