Although the synthesis of allenes has made considerable progress, methods for tetrasubstituted allenes are still limited. In this paper, the CuBr₂‐catalyzed cross‐coupling reaction of Grignard reagents and propargylic ammonium salts in tetrahydrofuran at 60 °C under argon delivered tetrasubstituted allenes in good to excellent yields. The reaction is thought to proceed by an S_N2′ pathway.

中文翻译：

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季铵盐和格氏试剂的铜催化合成四取代的烯

尽管丙二烯的合成取得了长足的进步，但是四取代丙二烯的方法仍然受到限制。本文在氩气下于60°C下于四氢呋喃中CuBr ₂催化的格氏试剂与炔丙基铵盐在四氢呋喃中的交叉偶联反应以良好的收率获得了良好的收率。该反应被认为是通过一个S进行_Ñ 2'通路。