To find PTP1B inhibitors from natural products, two new compounds (1 and 2), along with nine known compounds (3–11), were isolated from a methanol-soluble extract of Iris sanguinea seeds. The structures of compounds 1 and 2 were determined based on extensive spectroscopic data analysis including UV, IR, NMR, and MS. The IC₅₀ value of compound 5 on protein tyrosine phosphatase 1B (PTP1B) inhibitory activity is 7.30 ± 0.88 µM with a little activity compared to the IC₅₀ values of the tested positive compound. Compound 5 significantly enhanced glucose uptake and activation of pACC, pAMPK and partially Erk1/2 signaling. These results suggest that compound 5 from Iris sanguinea seeds are utilized as both PTP1B inhibitors and regulators of glucose uptake. These beneficial effects could be applied to treat metabolic diseases such as diabetes and obesity.

为了找到PTP1B抑制剂从天然产物中，两个新的化合物（1和2），具有九个已知化合物（沿3 - 11），从一个微溶于甲醇提取物中分离溪荪种子。基于广泛的光谱数据分析，包括UV，IR，NMR和MS，确定了化合物1和2的结构。该IC ₅₀化合物的值5对蛋白酪氨酸磷酸酶1B（PTP1B）的抑制活性是7.30±0.88μM用少量活性相比的IC ₅₀受试化合物正的值。化合物5显着增强了葡萄糖的摄取以及pACC，pAMPK和部分Erk1 / 2信号的激活。这些结果表明，来自鸢尾种子的化合物5被用作PTP1B抑制剂和葡萄糖摄取的调节剂。这些有益效果可用于治疗代谢性疾病，例如糖尿病和肥胖症。