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Nectrianolins A, B, and C, new metabolites produced by endophytic fungus Nectria pseudotrichia 120-1NP
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2017-09-14 , DOI: 10.1016/j.tetlet.2017.09.032
Nanang Rudianto Ariefta , Priska Kristiana , Handojo Hadi Nurjanto , Hiroyuki Momma , Eunsang Kwon , Tatsuya Ashitani , Keitaro Tawaraya , Tetsuya Murayama , Takuya Koseki , Hiroshi Furuno , Narandulam Usukhbayar , Ken-ichi Kimura , Yoshihito Shiono

Two sesquiterpene-epoxycyclohexenone conjugates, nectrianolins A (1) and B (2), together with a sesquiterpene, nectrianolin C (3), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP, an endophytic fungus isolated from Gliricidia sepium. Their structures were determined on the basis of 1D-/2D-NMR spectroscopy and HRESIMS data analyses in combination with chemical means. Nectrianolins A–C (13) exhibited cytotoxic activity against both HL60 and HeLa cells.



中文翻译:

Nectrianolins A,B和C,内生真菌Nectria pseudotrichia 120-1NP产生的新代谢产物

Nectria pseudotrichia 120-1NP的糙米培养物中分离出两种倍半萜烯-环氧环己烯酮共轭物Nectrianolins A(1)和B(2),以及倍半萜烯Nectrianolin C(3),这是一种分离自Gliricidia sepium的内生真菌。它们的结构是根据1D- / 2D-NMR光谱和HRESIMS数据分析结合化学方法确定的。Nectrianolins A-C(1 - 3)显示出细胞毒性活性对两种HL60细胞和HeLa细胞。

更新日期:2017-09-14
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