Download high-res imageOpen in new tabDownload PowerpointFans of the sci-fi seriesStar Trekare familiar with the show's fictional "tricorders," handheld devices used for sensor scanning and data analysis and recording. Yet these futuristic instruments are now, in a sense, entering the real world due to the advent of biosensors, devices that transform the detection of biological elements—antibodies, nucleic acids, cell receptors, enzymes, among others—into signals (e.g., optical, electrochemical) that can be more easily measured and quantified. The technology behind this modern-day measuring equipment is surface plasmon resonance (SPR), a process through which electrons on a metal surface are excited by a polarized light source, creating charge-density waves called plasmons. These plasmons then bend the light at a specific angle (known as the resonance angle) that is picked up through a detector. As molecules bind and dissociate from the metal surface, the resonance angle changes, giving an interaction profile (including binding kinetics, specificity, concentration, and affinity) that is recorded in real time. The possibilities for this technology include proteomics, immunogenicity, and drug discovery, but really are limitless. However, the best use for SPR is precision medicine. This tool could help to more quickly identify molecules or compounds that could aid in treatment of diseases. Conversely, it could also help pinpoint which patients would respond best to a particular drug or vaccine. Included in this booklet are articles fromScience,Science Translational Medicine, andScience Signalingthat detail the prospects for SPR technology.SPReading the word: The importance of binding kinetics ( PDF, 4.71 MB )View the online versionThis special supplement brought to you by theScience/AAAS Custom Publishing Office.

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赞助馆藏| SP读这个词：结合动力学的重要性

下载高分辨率图像在新标签中打开下载科幻系列《星际迷航》中的PowerpointFans，该节目虚构的“三阶”是手持设备，用于传感器扫描，数据分析和记录。然而，从某种意义上说，由于生物传感器的出现，这些未来主义的仪器现在进入了现实世界，生物传感器将将生物元素（抗体，核酸，细胞受体，酶等）的检测转化为信号（例如，光信号）的设备。 （电化学）），可以更轻松地对其进行测量和量化。这种现代测量设备背后的技术是表面等离子体激元共振（SPR），通过此过程，金属表面上的电子被偏振光源激发，从而产生称为等离子体激元的电荷密度波。然后，这些等离激元以特定角度（称为共振角）弯曲光，该特定角度通过检测器拾取。随着分子与金属表面的结合和解离，共振角发生变化，从而给出了实时记录的相互作用曲线（包括结合动力学，特异性，浓度和亲和力）。这项技术的可能性包括蛋白质组学，免疫原性和药物发现，但实际上是无限的。但是，SPR的最佳用途是精密医学。该工具可以帮助更快地识别有助于治疗疾病的分子或化合物。相反，它也可以帮助查明哪些患者对特定药物或疫苗的反应最佳。本手册中包括《科学》，《科学转化医学》，