In this issue of Blood, Mantuano et al in the Gonias laboratory elucidate a novel, protease-independent signaling pathway by which tissue plasminogen activator (tPA) negatively regulates the innate immune response of macrophages and neutralizes lipopolysaccharide (LPS) toxicity in vivo.1

中文翻译：

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巨噬细胞的 tPA 和愤怒管理

在本期血液中，Gonias 实验室的 Mantuano 等人阐明了一种新的、不依赖蛋白酶的信号通路，通过该通路，组织纤溶酶原激活剂 (tPA) 负向调节巨噬细胞的先天免疫反应并中和体内脂多糖 (LPS) 毒性。 1