We present vancomycin-loaded dual-function injectable hydrogel that delivers antibiotic locally suitable for treatment of infections in avascular or necrotic tissues. The syringe-deliverable gels were developed using polydextran aldehyde and an inherently antibacterial polymer N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride along with vancomycin. The antibiotic was primarily encapsulated via reversible imine bonds formed between vancomycin and polydextran aldehyde in the hydrogel which allowed sustained release of vancomycin over an extended period of time in a pH-dependent manner. Being inherently antibacterial, the gels displayed excellent efficacy against bacteria due to dual mode of action (killing bacteria upon contact as well as by releasing antibiotics into surroundings). Upon subcutaneous implantation, the gel was shown to kill methicillin-resistant Staphylococcus aureus (>99.999%) when bacteria were introduced directly into the gel as well as at distal site from the gel in a mice model. These materials thus represent as novel noninvasive drug-delivery device suitable for local antibiotic therapy.

中文翻译：

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双功能可注射水凝胶可控制释放抗生素和局部抗菌疗法

我们目前载有万古霉素的双功能可注射水凝胶，可局部递送抗生素，适合治疗无血管或坏死组织的感染。使用聚右旋糖醛和固有的抗菌聚合物N开发了可注射注射器的凝胶-（2-羟丙基）-3-三甲基氯化铵壳聚糖与万古霉素。抗生素主要通过万古霉素和聚葡聚糖醛之间在水凝胶中形成的可逆亚胺键进行封装，该亚胺键允许万古霉素在较长的时间内以pH依赖的方式持续释放。由于具有固有的抗菌作用，该凝胶由于双重作用方式（在接触时杀死细菌以及将抗生素释放到周围环境中而杀死细菌）显示出优异的抗细菌功效。皮下植入后，该凝胶被证明可以杀死耐甲氧西林的金黄色葡萄球菌（> 99.999％）在细菌模型中将细菌直接引入凝胶以及凝胶远端的细菌时。因此，这些材料代表了适用于局部抗生素治疗的新型无创药物输送装置。