A simple, reliable, and low-cost fabrication method is proposed here for assembling paper-based electrochemical devices (PEDs) using a commercial desktop digitally controlled plotter/cutter, together with ordinary writing tools. Permanent markers (tips of 1 mm) were used to create effective hydrophobic barriers on paper, while micromechanical pencils (mounting 4B graphite leads, 0.5 mm in diameter) were adopted for automatically drawn precise reference, counter, and working carbon electrodes. Fabrication parameters, such as writing pressure and speed, were first optimized, and the electrochemical performance of these devices was then evaluated by using potassium hexacyanoferrate(II) as redox probe. The good interdevice reproducibility (4.8%) displayed by the relevant voltammetric responses confirmed that this strategy can be profitably adopted to easily assemble paper-based electrochemical devices in a highly flexible manner. The simplicity of the instrumentation used and the low cost of each single device (about $0.04), together with the speed of fabrication (about 2 min), are other important features of the proposed strategy. Finally, to confirm the effectiveness of this prototyping method for the analysis of real samples and rapid controls, PEDs assembled by this simple approach were successfully exploited for the analysis of vitamin B₆ in food supplements.

中文翻译：

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组装完全绘制的纸基电分析平台的数控程序

本文提出了一种简单，可靠且低成本的制造方法，用于使用商用台式数字控制绘图仪/刀具以及普通书写工具来组装纸基电化学装置（PED）。永久性标记（尖端为1毫米）用于在纸上创建有效的疏水性屏障，而微机械铅笔（可安装4B石墨导线，直径为0.5毫米）用于自动绘制精确的参比电极，对电极和工作碳电极。首先优化制造参数，例如书写压力和速度，然后使用六氰合铁酸钾（II）作为氧化还原探针评估这些器件的电化学性能。良好的设备间重现性（4。由相关伏安响应显示的8％）证实，该策略可被有利地采用，以高度灵活的方式轻松组装纸基电化学装置。所使用的仪器的简单性和每个单个设备的低成本（约0.04美元）以及制造速度（约2分钟）是所提出策略的其他重要特征。最后，为证实该原型方法对真实样品和快速对照进行分析的有效性，通过这种简单方法组装的PED被成功地用于维生素B的分析 是拟议策略的其他重要特征。最后，为证实该原型方法对真实样品和快速对照进行分析的有效性，通过这种简单方法组装的PED被成功地用于维生素B的分析 是拟议策略的其他重要特征。最后，为证实该原型方法对真实样品和快速对照进行分析的有效性，通过这种简单方法组装的PED被成功地用于维生素B的分析₆在食品补品中。