Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced by the monoamine storage blocker tetrabenazine. Tetrabenazine shifted effort-related choice in rats, decreasing high-effort lever pressing but increasing chow intake. The effects of tetrabenazine were reversed by oral ingestion of curcumin (80.0–160.0 mg/kg) and infusions of curcumin into the cerebral ventricles (2.0–8.0 μg). Curcumin attenuates the effort-related effects of tetrabenazine in this model via actions on the brain, suggesting that curcumin may be useful for treating human motivational symptoms.

中文翻译：

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口服摄入和脑室内注射姜黄素可减轻VMAT-2抑制剂Tetrabenazine的努力相关作用：对抑郁动机症状的影响

与工作有关的选择任务用于研究抑郁性动机症状，如无痛/疲劳。这些研究调查了膳食补充姜黄素逆转由单胺存储阻断剂丁苯那嗪引起的低努力偏倚的能力。川tra嗪改变了大鼠与努力有关的选择，减少了高强度的杠杆按压，但增加了食物摄入量。口服摄入姜黄素（80.0–160.0 mg / kg）和将姜黄素输注到脑室（2.0–8.0μg）可逆转丁苯那嗪的作用。在该模型中，姜黄素通过对大脑的作用减弱了丁苯那嗪与工作有关的作用，表明姜黄素可能对治疗人的动机症状有用。