DNA origami makes it feasible to fabricate a tremendous number of DNA nanostructures with various geometries, dimensions, and functionalities. Moreover, an increasing amount of research on DNA nanostructures is focused on biological and biomedical applications. Here, the reversible regulation of microcosmic structural rigidity is accomplished using a DNA origami device in vitro. The designed DNA origami monomer is composed of an internal central axis and an external sliding tube. Due to the external tube sliding, the device transforms between flexible and rigid states. By transporting the device into the liposome, the conformational change of the origami device induces a structural change in the liposome. The results obtained demonstrate that the programmed DNA origami device can be applied to regulate the microcosmic structural rigidity of liposomes. Because microcosmic structural rigidity is important to cell proliferation and function, the results obtained potentially provide a foundation for the regulation of cell microcosmic structural rigidity using DNA nanostructures.

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DNA折纸机械装置，用于调节微观结构的刚度

DNA折纸使制造具有各种几何形状，尺寸和功能的大量DNA纳米结构成为可能。而且，关于DNA纳米结构的越来越多的研究集中在生物和生物医学应用上。在这里，微观结构刚性的可逆调节是在体外使用DNA折纸装置完成的。设计的DNA折纸单体由内部中心轴和外部滑动管组成。由于外管的滑动，该设备在柔性和刚性状态之间转换。通过将装置运输到脂质体中，折纸装置的构象变化引起脂质体的结构变化。获得的结果表明，程序化的DNA折纸装置可用于调节脂质体的微观结构刚性。因为微观结构的刚性对细胞增殖和功能很重要，所以获得的结果可能为使用DNA纳米结构调节细胞微观结构的刚性提供基础。