A new mild and efficient process for the aqueous preparation of aldehydes, which are employed as flavour and fragrance components in food, beverage, cosmetics, as well as in pharmaceuticals, was developed using a continuous‐flow approach based on an immobilised pure transaminase‐packed bed reactor. HEWT, an ω‐transaminase from the haloadapted bacterium Halomonas elongata, has been selected for its excellent stability and substrate scope. Sixteen different amines were rapidly (3–15 min) oxidised to the corresponding aldehydes (90 to 99 %) with only 1 to 5 equivalents of sodium pyruvate. The process was fully automated, allowing for the in‐line recovery of the pure aldehydes (chemical purity >99 % and isolated yields above 80 %), without any further work‐up procedure.

中文翻译：

---

基于流的生物催化将胺高效氧化为醛

基于固定化纯转氨酶包装的连续流方法，开发了一种温和而有效的醛醛水溶液制备方法，该方法被用作食品，饮料，化妆品以及药物中的风味和香气成分。床反应器。HEWT是一种来自已重载的细菌Halomonas elongata的ω-转氨酶，因其出色的稳定性和底物范围而被选择。仅使用1至5当量的丙酮酸钠，将16种不同的胺迅速（3–15分钟）氧化为相应的醛（90至99％）。该过程是完全自动化的，可以在线回收纯醛（化学纯度> 99％，分离的收率超过80％），而无需进行任何后续处理。