How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.

中文翻译：

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与星共舞：酚类糖脂与巨噬细胞结合

麻风分枝杆菌感染如何引起脱髓鞘介导麻风病发病机制一直是一个长期存在的问题。在最近的Cell论文中，Madigan等人。（2017）使用斑马鱼麻风分枝杆菌感染的斑马鱼模型显示，被感染的巨噬细胞巡逻轴突引发线粒体损伤并诱导神经细胞脱髓鞘。