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Photoredox organocatalytic α-amino C(sp3)–H functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-09-06 00:00:00 , DOI: 10.1039/c7qo00644f
Jing Liu 1, 2, 3, 4, 5 , Jin Xie 1, 2, 3, 4, 5 , Chengjian Zhu 1, 2, 3, 4, 5
Affiliation  

A 5-membered heterocyclic γ-amino acid scaffold possesses a wide range of bioactivities. Herein, we report a photoredox organocatalytic, highly selective α-amino C(sp3)–H bond functionalization to generate a reactive α-amino radical, which undergoes conjugate addition to Michael acceptors, providing an elegant intramolecular access to cyclic γ-amino acid analogues in satisfactory yields.

中文翻译:

光氧化还原有机催化α-氨基C(sp 3)–H官能团用于合成5元杂环γ-氨基酸衍生物

5元杂环γ-氨基酸支架具有广泛的生物活性。在本文中,我们报道了光氧化还原有机催化,高度选择性的α-氨基C(sp 3)–H键官能化以生成反应性α-氨基自由基,该自由基经过迈克尔共轭物的共轭加成,提供了对环状γ-氨基酸的优雅分子内通路类似物以令人满意的产率。
更新日期:2017-09-14
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