A group of photochemical nitric oxide (NO) delivery agents, O²-(4-hydroxyphenacyl) diazeniumdiolates 1–2 as well as O²-(3-(benzothiazole-2-yl)-4-hydroxyphenacyl) diazeniumdiolates 3–4, could be triggered by ultraviolet light (365–400 nm) and visible light (≥410 nm), respectively, to produce NO in cancer cells and generate potent antitumor activity. Importantly, with the photolysis of 3 being initiated, the accompanying distinct fluorescence color change (from green to blue) may act as a qualitative real-time optical indicator for NO release in cancer cells.

中文翻译：

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新型O ²衍生的二氮杂二氮烯二醇盐的合成与评价作为光化学和实时监测一氧化氮的输送剂

一组光化学一氧化氮（NO）输送剂，O ^2-（4-羟基苯甲酰基）二氮烯二醇盐1-2以及O ^2-（3-（苯并噻唑-2-基）-4-羟基苯甲酰基）二氮烯二醇盐3-4，紫外线（365-400 nm）和可见光（≥410nm）分别触发可在癌细胞中产生NO并产生有效的抗肿瘤活性。重要的是，随着3的光解作用的开始，随之而来的明显的荧光颜色变化（从绿色到蓝色）可以作为癌细胞中NO释放的定性实时光学指示剂。