Bacterial cellulose (BC) membrane is a promising biopolymer which can be used for tissue implants, wound healing, and drug delivery due to its unique properties, such as high crystallinity, high mechanical strength, ultrafine fiber network structure, good water holding capacity and biocompatibility. However, BC does not intrinsically present antibacterial properties. In the present study, functionalized BC membranes were prepared. FTIR, SEM and XPS were used to characterize the chemical composition and surface morphology. Static water contact angles were measured to investigate surface wettability. Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans were used to evaluate the antibacterial properties of membranes. HEK293 cell lines were applied to assess the biocompatibility of membrane surfaces by MTT assay and their morphologies were observed by Confocal Microscopy. Interestingly, the resultant functionalized BC membranes exhibiting excellent antibacterial property and good biocompatibility demonstrated great utility and potential as biomaterial materials.

中文翻译：

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细菌纤维素膜的新型生物活性表面功能化。

细菌纤维素（BC）膜是一种很有前途的生物聚合物，由于其独特的特性（例如高结晶度，高机械强度，超细纤维网络结构，良好的保水能力和生物相容性），可用于组织植入物，伤口愈合和药物输送。 。但是，BC并没有固有的抗菌特性。在本研究中，制备了功能化的BC膜。FTIR，SEM和XPS用于表征化学成分和表面形态。测量静态水接触角以研究表面润湿性。大肠杆菌，金黄色葡萄球菌，枯草芽孢杆菌和白色念珠菌用于评估膜的抗菌性能。应用HEK293细胞系通过MTT法评估膜表面的生物相容性，并通过共聚焦显微镜观察其形态。有趣的是，所得的显示出优异的抗菌性能和良好的生物相容性的功能化BC膜具有巨大的实用性和作为生物材料的潜力。