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Moving On Out: Transport and Packaging of Influenza Viral RNA into Virions
Annual Review of Virology ( IF 11.3 ) Pub Date : 2016-10-14 00:00:00 , DOI: 10.1146/annurev-virology-110615-042345
Seema S. Lakdawala 1 , Ervin Fodor 2 , Kanta Subbarao 3
Affiliation  

Influenza A viruses bear an eight-segmented single-stranded negative-sense RNA genome that is replicated in the nucleus. Newly synthesized viral RNA (vRNA) segments are exported from the nucleus and transported to the plasma membrane for packaging into progeny virions. Influenza viruses exploit many host proteins during these events, and this is the portion of the viral life cycle when genetic reassortment among influenza viruses occurs. Reassortment among influenza A viruses allows viruses to expand their host range, virulence, and pandemic potential. This review covers recent studies on the export of vRNAs from the nucleus and their transport through the cytoplasm, progressive assembly, and packaging into progeny virus particles. Understanding these events and the constraints on genetic reassortment has implications for assessment of the pandemic potential of newly emerged influenza viruses, for vaccine production, for determination of viral fitness, and for identification of novel therapeutic targets.

中文翻译:


继续前进:将流感病毒RNA运输和包装到病毒颗粒中

甲型流感病毒带有八节单链负义RNA基因组,可在细胞核中复制。新合成的病毒RNA(vRNA)片段从细胞核中输出,并运输到质膜以包装成后代病毒体。在这些事件中,流感病毒利用许多宿主蛋白,这是流感病毒之间发生基因重组时病毒生命周期的一部分。甲型流感病毒之间的重排使病毒可以扩大其宿主范围,毒力和大流行潜力。这篇综述涵盖了有关vRNA从细胞核中的输出及其在细胞质中的运输,逐步装配以及包装成子代病毒颗粒的最新研究。

更新日期:2016-10-14
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